NAD+ Patches

What is NAD⁺?

• NAD⁺ is a coenzyme found in every living cell.

• It plays a central role in metabolism - helping convert nutrients (carbohydrates, fats, proteins) into usable cellular energy (ATP).

• NAD⁺ exists in two main forms:

  • NAD⁺ (oxidized form)

  • NADH (reduced form)
    These forms shuttle electrons during cellular respiration, fueling energy production in mitochondria.

Key Functions of NAD⁺

1. Energy Production

   • NAD⁺ accepts and donates electrons in the Krebs cycle and electron transport chain, making ATP - the cell’s energy currency.

2. DNA Repair

   • NAD⁺ is required for the activity of enzymes called PARPs (Poly ADP-ribose polymerases) that repair damaged DNA.

3. Cell Signaling & Stress Response

   • It activates sirtuins, a family of proteins linked to longevity, metabolism, and inflammation control.

4. Metabolic Regulation

   • Influences insulin sensitivity, mitochondrial health, and lipid/glucose metabolism.

5. Aging & Longevity Research

   • NAD⁺ levels decline with age. This decline is associated with reduced cellular repair, lower energy, inflammation, and age-related conditions.

   • Boosting NAD⁺ is being studied for anti-aging and disease prevention potential.